For the past few years we have been interested in the synthesis, characterization and bioactivity of a series of compounds containing both a trisubstituted tin functional group and a dithiocarbamate functional group. The compounds we are making have carbon spacers separating the tin and sulfur groups:
R = Me, Bu, Ph
n = 4, 6
We have also used a cyclohexane ring as a spacer. The synthetic chemistry has led us to a study of the conformational equilibria of cis- and trans- 1, 4-bromochlorocylohexane.