Evelyn Voura

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Evelyn Voura

Evelyn Voura

Visiting Assistant Professor
Biology, 315 Olin Hall
p 315-228-6271

Degree

BSc University of Guelph 1992; MSc University of Toronto 1994; PhD University of Toronto 1999

Teaching Experience

Assistant Professor of Biology, Dominican College 2011-2014; Adjunct Professor, Vassar College 2010-2011, Adjunct Professor, Marist College 2009-2010

Professional Experience

Research Coordinator/Assistant Director of Research, NYU Langone Medical Center 2005-2014; Post-doctoral Fellow, Rockefeller University 2001-2005; Post-doctoral Fellow, Ontario Cancer Institute at Princess Margaret Hospital 1999-2001

Interests

My research program focuses on the use of the planarian flatworm as a three-dimensional tumor model. Planarians generate tumors quickly, and their rich supply of stem cells offers an excellent opportunity to examine the behavior of these cells during tumorigenesis. I am currently working on developing three essential aspects of the model. The first is to modulate the growth of cadmium induced tumor growth using metabolic inhibitors and drugs. The planarian has already established itself as an excellent model for testing the effects of stimulants, and to perfect our use of the planarian for drug testing, I am examining the effects of nutritional supplements in healthy worms. The second aspect of the planarian tumor model being studied in the lab is the establishment of a tumor cell invasion model by grafting whole tumors and dissociated tumor cells to healthy worms. The final aspect of the model being worked out is a means to study the relationship of stem cells with tumors. I am working on ways to monitor the motility of planarian stem cells in response to tumors and tumor growth conditions in comparison to wound healing and regeneration.

Publications

Morsi A, Voura EB, Golfinos JG, Zaim Wadghiri Y. Induction of brain metastasis in mice via internal carotid injection. The Journal of Visualized Experiments 2013 (in press).

Hoang DM, Voura EB, Zhang C, Fakri-Bouchet L, Zaim Wadghiri Y. Evaluation of RF coils for imaging histological slides: SNR and filling factor. Magnetic Resonance in Medicine 2014 71(5): 1932-1943.

Voura EB, English JL, Yu HYE, Ho AT, Subarsky P, Hill RP, Hojilla CV, DiGrappa MA, Khokha. R. Proteolysis during tumor cell extravasation in vitro: metalloproteinase involvement across tumor cell types. PLoS One 2013 8(10):e78413.

Zagzag D, Lukyanov Y, Lan L, Ali MA, Esencay M, Mendez O, Yee H, Voura EB, Newcome EW. Hypoxia-inducible factor 1 and VEGF upregulate CXCR4 in glioblastoma: implications for angiogenesis and glioma cell invasion. Laboratory Investigation 2006 86(12):1221-1232.

Khokha R, Voura EB, Hill RP. Tumor progression and metastasis: cellular, molecular and mircroenvironmental factors.  Chapter 11: 205-230. The Basic Science of Oncology, 4th Edition, Edited by Tannock IF, Hill RP, Harrington L, and Bristow RG, McGraw-Hill, 2005.

Voura EB, Jaiswal JK, Mattoussi H, Simon SM. Tracking metastatic tumor cell extravasation with quantum dot nanocrystals and fluorescence emission-scanning microscopy. Nature Medicine 2004 10(9):993-998.

Fata JE, Leco KJ, Voura EB, Yu HY, Waterhouse P, Murphy G, Moorehead RA, Khokha R. Accelerated apoptosis in the Timp-3-deficient mammary gland. Journal of Clinical Investigation 2001 108(6):831-41.

Voura EB, Ramjeesingh RA, Montgomery AM, Siu CH. Involvement of integrin avb3 and cell adhesion molecule L1 in transendothelial migration of melanoma cells. Molecular Biology of the Cell 2001 12(9):2699-710.

Ho AT, Voura EB, Soloway PD, Watson KL, Khokha R. MMP inhibitors augment fibroblast adhesion through stabilization of focal adhesion contacts and up-regulation of cadherin function. Journal of Biological Chemistry 2001 276(43):40215-24.

Voura EB, Chen N, Siu CH. Platelet-endothelial cell adhesion molecule-1 (CD31) redistributes from the endothelial junction and is not required for the transendothelial migration of melanoma cells. Clinical & Experimental Metastasis 2000 18(6):527-32.

Fata JE, Kong YY, Li J, Sasaki T, Irie-Sasaki J, Moorehead RA, Elliott R, Scully S, Voura EB, Lacey DL, Boyle WJ, Khokha R, Penninger JM. The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development. Cell 2000 103(1):41-50.

Voura EB, Sandig M, Siu CH. Cell-cell interactions during transendothelial migration of tumor cells. Microscopy Research and Technique 1998 43(3):265-75. Review.

Voura EB, Sandig M, Kalnins VI, Siu C. Cell shape changes and cytoskeleton reorganization during transendothelial migration of human melanoma cells. Cell and Tissue Research 1998 293(3):375-87. Journal Cover Photo.

Sandig M, Voura EB, Kalnins VI, Siu CH. Role of cadherins in the transendothelial migration of melanoma cells in culture. Cell Motility and the Cytoskeleton 1997 38(4):351-64.

Voura EB, Billia F, Iscove NN, Hawley RG. Expression mapping of adhesion receptor genes during differentiation of individual hematopoietic precursors. Experimental Hematology 1997 25(11):1172-9.

Brady G, Billia F, Knox J, Hoang T, Kirsch IR, Voura EB, Hawley RG, Cumming R, Buchwald M, Siminovitch K. Analysis of gene expression in a complex differentiation hierarchy by global amplification of cDNA from single cells. Current Biology 1995 5(8):909-22.